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| Section | Objectives |
|---|---|
| Reproductive Endocrinology | - Polycystic ovary syndrome (PCOS) - Hypogonadism and infertility |
| Diabetes Mellitus | - Type 1 and Type 2 diabetes management - Diabetic complications and emergencies |
| Endocrine Emergencies | - Diabetic ketoacidosis and hyperosmolar states - Thyroid and adrenal crisis |
| Metabolic Disorders | - Lipid disorders - Obesity management |
| Calcium, Bone and Metabolic Disease | - Osteoporosis and metabolic bone disease - Calcium and vitamin D disorders |
| Thyroid Disease | - Thyroid nodules and cancer - Hyperthyroidism and hypothyroidism |
| Neuroendocrine Tumours and Multiple Endocrine Neoplasia | - Carcinoid and pancreatic NETs - MEN syndromes |
| Pituitary and Hypothalamic Disorders | - Pituitary adenomas and hypopituitarism - Diabetes insipidus and SIADH |
| Adrenal Disorders | - Addison disease and adrenal insufficiency - Cushing syndrome |
1. A 56-year-old man was referred to the diabetes clinic for conversion to insulin. He was taking metformin 1 g three times daily, gliclazide 160 mg twice daily and pioglitazone 45 mg daily. He drank no alcohol.
On examination, his body mass index was 41 kg/m2 (18-25). Abdominal examination showed a 2-cm, smooth, non-tender liver edge.
Which liver function test is the best marker of non-alcoholic fatty liver disease in type 2 diabetes mellitus?
A) alanine aminotransferase
B) gamma glutamyl transferase
C) bilirubin
D) aspartate aminotransferase
E) alkaline phosphatase
2. A 25-year-old woman presented with a solitary nodule in the right lobe of her thyroid gland.
Investigations:
serum thyroid-stimulating hormone0.45 mU/L (0.4-5.0)
serum free T420.7 pmol/L (10.0-22.0)
The presence of which feature would most increase the likelihood of malignancy?
A) increased peripheral vascularity of nodule on Doppler ultrasound
B) microcalcification seen within the nodule on ultrasound scan
C) high titre of thyroid peroxidase antibodies
D) size of nodule >1.0 cm in maximum diameter
E) elevated serum thyroglobulin concentration
3. A 25-year-old woman with type 1 diabetes mellitus was admitted to hospital with a 12-hour
history of nausea and lethargy.
On examination, her temperature was 37.5C, she was dehydrated and her Glasgow coma
score was 14. Urinalysis showed glucose 2+, ketones 3+, protein negative.
Investigations:
white cell count12.0 ? 109/L (4.0-11.0)
neutrophil count8.0 ? 109/L (1.5-7.0)
random plasma glucose22.0 mmol/L
arterial blood gases, breathing air:
pH7.20 (7.35-7.45)
serum C-reactive protein12 mg/L (<10)
She was treated with intravenous sodium chloride 0.9% and fixed-rate intravenous insulin
infusion, and initially improved. Twelve hours into her admission, she complained of a
headache.
On examination, her temperature was 37.3C and her Glasgow coma score was 15. Her
pulse was 85 beats per minute and her blood pressure was 110/70 mmHg. There was no
neck stiffness, papilloedema or focal neurological signs.
What is the most likely cause for her headache?
A) cerebral oedema
B) tension headache
C) bacterial meningitis
D) viral encephalitis
E) sagittal sinus thrombosis
4. A 50-year-old woman with acromegaly presented with persistent sweating and headaches
despite having undergone trans-sphenoidal surgery and pituitary radiotherapy 2 years
previously. She had been intolerant of treatment with octreotide.
Investigations:
serum growth hormone11.1 ?g/L (<0.4)
serum insulin-like growth factor 186.2 nmol/L (5.6-23.3)
Following imaging, it was judged that there was no role for repeat surgery. She was treated
with pegvisomant 10 mg. Six months into treatment, her symptoms had improved.
Investigations (6 months later):
serum growth hormone20.3 ?g/L (<0.4)
serum insulin-like growth factor 115.2 nmol/L (5.6-23.3)
What is the most appropriate next step in management?
A) increase dosage of pegvisomant
B) add cabergoline
C) arrange another full course of pituitary radiotherapy
D) continue present dosage of pegvisomant
E) stop pegvisomant
5. A 17-year-old boy was concerned about his height. He had been treated for Crohn's disease since the age of 13 with a combination of topical and systemic corticosteroids and azathioprine. He was currently taking mercaptopurinE.
On examination, his height was on the 25th centile.
Investigations:
X-ray of right kneesee image
What is the most appropriate next step in management?
A) investigate for growth hormone deficiency
B) refer for leg lengthening surgery
C) advise him that he will continue to grow for 12 months
D) treat with growth hormone
E) advise him that growth is complete
Solutions:
| Question # 1 Answer: A | Question # 2 Answer: B | Question # 3 Answer: B | Question # 4 Answer: D | Question # 5 Answer: E |
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